Serum Proteins Capillary Zone Electrophoresis: A Comparison of Two Systems

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Detection of monoclonal proteins by capillary zone electrophoresis: comparison of 2 multichannel automated systems.

To the Editor: Capillary zone electrophoresis (CZE) is an alternative method for separation of serum proteins (1 ). Two dedicated and automated multichannel instruments are available, the Paragon 2000 (Beckman-Coulter) and the Capillarys (Sebia). The sensitivity and specificity of Paragon 2000 for detection of monoclonal proteins have been reported to be 95% (2–4) and 78% (4 ), respectively. Th...

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Evaluation of Acetonitrile Deproteinisation of the Serum Samples for the Analysis of Drugs in Serum Using Capillary Zone Electrophoresis

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Evaluation of Acetonitrile Deproteinisation of the Serum Samples for the Analysis of Drugs in Serum Using Capillary Zone Electrophoresis

Deproteinisation with acetonitrile (along with methanol or other reagents) is a useful and rapid technique in analysis of drugs or their metabolites in human serum. In this paper application of this simple technique in biopharmaceutical analysis using capillary electrophoresis (CE) is evaluated. Some drugs with different ionic and protein binding properties were selected and dissolved in human ...

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Evaluation of Acetonitrile Deproteinisation of the Serum Samples for the Analysis of Drugs in Serum Using Capillary Zone Electrophoresis

Deproteinisation with acetonitrile (along with methanol or other reagents) is a useful and rapid technique in analysis of drugs or their metabolites in human serum. In this paper application of this simple technique in biopharmaceutical analysis using capillary electrophoresis (CE) is evaluated. Some drugs with different ionic and protein binding properties were selected and dissolved in human ...

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ژورنال

عنوان ژورنال: Laboratory Medicine

سال: 2006

ISSN: 0007-5027

DOI: 10.1309/e8p5-gxdw-akdp-3b0q